TOTECT®
Generic name: Dexrazoxane
Pronounciation: dex-ra-ZOX-ane
Brand name: TOTECT®
What TOTECT® is and what it is used for:
Totect is a treatment for anthracycline chemotherapy extravasation.
Many chemotherapy drugs are given I.V. (into a vein). They sometimes leak from the vein or go into the tissue instead of the vein. When an anthracycline (a type of chemotherapy drug) goes into the tissue, damage to the tissue can occur. This is called an anthracycline extravasation.
Do NOT use TOTECT® if:
-- you are allergic to dexrazoxane or any of the other ingredients in Totect.
-- you have an extravasation of a chemotherapy drug that is not an anthracycline.
Before using TOTECT®:
Tell your healthcare provider if you have any medical conditions, especially if any of the following. apply to you:
--if you are pregnant or could be pregnant, are planning to become pregnant, or are breastfeeding.
--if you have any kidney or liver problems
--if you are taking any prescription or nonprescription medicine, herbal preparations, or dietary supplements.
How to use TOTECT®:
--Use Totect as directed by your healthcare provider.
--Totect is usually administered at a doctor’s office, clinic, or hospital.
--Totect is given I.V. into a vein over 1-2 hours each day for a total of three days.
--The first dose of Totect needs to be given within 6 hours of an anthracycline extravasation. The second dose is given 24 hours later on the second day and the last dose is given at about the same time on the third day.
Important safety information about TOTECT®:
--Blood tests may be needed to monitor your progress or check for side effects. Be sure to keep all lab and doctor’s appointments.
--Totect should not be given to children. Safety and effectiveness in children have not been confirmed.
Possible side effects of TOTECT®:
The most common side effect of Totect is nausea. Other possible side effects are pain at the injection site, decreased white blood cell count, diarrhea, dry mouth, hair loss, and tiredness. Contact your healthcare provider if any of these side effects persist or become bothersome.
If you have questions or need medical advice about side effects, contact your healthcare provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at www.fda.gov/medwatch.
General Information:
--If you have any questions about Totect, talk to your doctor, nurse, pharmacist, or other healthcare provider.
--This information is a summary only and does not contain all information about Totect. If you would like more information, contact your healthcare provider.
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