| | COMMITMENT to EXTRAVASATION TREATMENT |

| Novel research led to the only FDA approved product for treating anthracycline extravasation. |

| TOTECT® may reduce the providers medico-legal risks and healthcare costs associated with anthracycline extravasations. |

| TopoTarget provides the educational platform to increase awareness, detection and prevention of anthracycline extravasations. |

| TOTECT® has orphan drug marketing exclusivity and is the only patent-protected dexrazoxane for treating anthracycline extravasations. |

| TOTECT® Now offers a Six-Year Replacement Kit Policy on all Purchased Kits. |
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