Totect

Anthracycline extravasation happens - know how to respond.

DISCOVER the ANTIDOTE to anthracycline extravasation

  • The only FDA approved anthracycline extravasation antidote2
  • Highly effective in reducing tissue damage3
  • Eliminated the need for surgery in 98% of patients in clinical studies3
  • Allows for the majority of patients to continue their next scheduled dose of cancer therapy on time3,4

 

References:
1. Langer SW. Curr Oncol Rep. 2010 May;12:242-246. 2. TOTECT® [prescribing information]. Nashville, TN; Cumberland Pharmaceuticals; June 2017. 3. Mouridsen HT et al. Ann Oncol. 2007 Mar;18(3):546-50. Epub 2006 Dec 21. 4. Fontaine C et al. Support Care Cancer. 2012 May;20(5):1109-12. doi:10.1007/s00520-012-1382-2. Epub 2012 Jan 27.
Know How To Respond

INDICATION: TOTECT® (dexrazoxane) is indicated for the treatment of extravasation resulting from intravenous anthracycline chemotherapy.

IMPORTANT DOSAGE AND ADMINISTRATION INSTRUCTIONS
Vial contents must be mixed and diluted with 50 mL of 0.167 M sodium lactate injection solution before use. The TOTECT dose should be reduced by 50% in patients with creatinine clearance
values < 40 mL/min.

IMPORTANT SAFETY INFORMATION
CONTRAINDICATIONS

None.

WARNINGS AND PRECAUTIONS
Myelosuppression: TOTECT is associated with leukopenia, neutropenia, and thrombocytopenia. Perform hematological monitoring.
Use in Pregnancy: Fetal harm can occur when administered to a pregnant woman. Apprise women of potential harm to the fetus.

ADVERSE REACTIONS
In the clinical studies, TOTECT was administered to patients also receiving chemotherapeutic agents for cancer, and the adverse reaction profile reflects the combination of TOTECT, underlying disease, and already administered chemotherapy. The most common adverse reactions (≥16%) are nausea, fever, injection site pain and vomiting.

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